Drug Information

Drug General Information
Drug ID
D0KX9B
Former ID
DNCL002804
Drug Name
EP-101
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Phase 2 [523605]
Company
Elevation Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C8H12O
Canonical SMILES
C=CC1CCC2C(C1)O2
InChI
1S/C8H12O/c1-2-6-3-4-7-8(5-6)9-7/h2,6-8H,1,3-5H2
InChIKey
SLJFKNONPLNAPF-UHFFFAOYSA-N
PubChem Compound ID
7832
PubChem Substance ID
92519, 5964499, 8155380, 15321303, 24849235, 29226618, 49999767, 56367848, 57324518, 80447510, 88835268, 104316107, 117394656, 117394657, 121278413, 125643625, 126564565, 126676587, 128317810, 129253052, 131293880, 134972080, 137181223, 142310814, 143490727, 152041149, 152235330, 162096454, 163306405, 163415435, 163803152, 164791602, 165374121, 172089146, 172886474, 176325026, 184586929, 204425894, 210024047, 223653908, 223773569, 226419812, 249852374, 250216422, 252032301, 252404318, 252465773
Target and Pathway
Target(s) Muscarinic receptor Target Info Antagonist [532169]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 523605ClinicalTrials.gov (NCT01426009) Study to Investigate the Dose Response, Safety and Efficacy of Nebulized EP-101 in Patients With Chronic Obstructive Pulmonary Disease (COPD): GOLDEN-1 Study. U.S. National Institutes of Health.
Ref 532169Long-acting muscarinic receptor antagonists for the treatment of respiratory disease. Pulm Pharmacol Ther. 2013 Jun;26(3):307-17.

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