Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0KJ9P
|
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| Former ID |
DNCL002427
|
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| Drug Name |
LDK378
|
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| Drug Type |
Small molecular drug
|
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| Company |
Novartis Pharmaceuticals
|
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| Formula |
C28H36ClN5O3S
|
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| InChI |
InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)
|
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| InChIKey |
VERWOWGGCGHDQE-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
136885241, 141684342, 162121758, 163686322, 164046418, 164178310, 172650708, 174522973, 175449167, 175605567, 178103969, 184825397, 198981892, 198994001, 210280921, 223382060, 223404362, 224194290, 226088024, 227267564, 242060137, 247314720, 252091144, 252160836, 252215680, 252450501, 252472270, 252543471
|
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| Target and Pathway | |||||
| Target(s) | ALK tyrosine kinase receptor | Target Info | Modulator | [542418] | |
| KEGG Pathway | Non-small cell lung cancer | ||||
| WikiPathways | Differentiation Pathway | ||||
| References | |||||
| Ref 533123 | 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. | ||||
| Ref 542418 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7397). | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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