| Drug General Information |
| Drug ID |
D0K9UK
|
| Former ID |
DIB016607
|
| Drug Name |
E-6700
|
| Indication |
Asthma [ICD10:J45]
|
Phase 2 |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| CAS Number |
CAS 144562-61-8
|
| Target and Pathway |
| Target(s) |
Arachidonate 5-lipoxygenase |
Target Info |
Modulator |
[1]
|
|---|
| Thromboxane-A synthase |
Target Info |
Modulator |
[1]
|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
|
Resolvin D biosynthesis
|
|
Leukotriene biosynthesis
|
|
Lipoxin biosynthesis
|
|
Aspirin triggered resolvin D biosynthesis
|
|
Aspirin triggered resolvin E biosynthesisPWY66-374:C20 prostanoid biosynthesis
|
|
KEGG Pathway
|
Arachidonic acid metabolism
|
|
Metabolic pathways
|
|
Serotonergic synapse
|
|
Ovarian steroidogenesis
|
|
Toxoplasmosishsa00590:Arachidonic acid metabolism
|
|
Platelet activation
|
|
NetPath Pathway
|
IL4 Signaling Pathway
|
|
PathWhiz Pathway
|
Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
|
|
WikiPathways
|
Vitamin D Receptor Pathway
|
|
Arachidonic acid metabolism
|
|
Eicosanoid Synthesis
|
|
Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
|
|
Phase 1 - Functionalization of compounds
|
| References |
| REF 1 | Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. J Med Chem. 1996 Aug 2;39(16):3148-57. |
|---|
