Drug Information
Drug General Information | |||||
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Drug ID |
D0K9MY
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Former ID |
DCL000639
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Drug Name |
Saxagliptin
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Synonyms |
Onglyza; BMS 477118-11; BMS-477118; Kombiglyze XR (TN); OPC-262; Onglyza (TN); BMS-477118-11; (1S,5S)-2-[2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3
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Drug Type |
Small molecular drug
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Company |
Bristol-Myers Squibb; AstraZeneca
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Structure |
Download2D MOL |
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Formula |
C18H25N3O2
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InChI |
InChI=1S/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1
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InChIKey |
QGJUIPDUBHWZPV-SGTAVMJGSA-N
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CAS Number |
CAS 361442-04-8
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PubChem Compound ID | |||||
PubChem Substance ID |
16328544, 16675586, 23422497, 42323525, 46512075, 57304394, 75512904, 92722527, 96025679, 99443245, 103500900, 104096574, 104253199, 121147387, 121362351, 123051077, 124758670, 124772084, 126618190, 126644889, 136340362, 137251549, 139567127, 144076400, 144206461, 152035966, 160655903, 160967860, 162011574, 162164961, 175267813, 175610961, 178102934, 184811995, 223668663, 223705237, 224543974, 225361148, 226407286, 246280642, 251970941, 252154978, 252447400
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SuperDrug ATC ID |
A10BH03
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Target and Pathway | |||||
Target(s) | Dipeptidyl peptidase IV | Target Info | Inhibitor | [530677], [537022], [550288] | |
KEGG Pathway | Protein digestion and absorption | ||||
NetPath Pathway | IL2 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | |||||
References | |||||
Ref 530677 | Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. | ||||
Ref 541462 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6316). | ||||
Ref 530677 | Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. | ||||
Ref 537022 | Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. | ||||
Ref 550288 | Clinical pipeline report, company report or official report of AstraZeneca (2009). |
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