Drug Information

Drug General Information
Drug ID
D0K9KS
Former ID
DIB008574
Drug Name
Draculin
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Terminated [545778]
Company
Instituto Venezolano de Investigaciones Cientificas
CAS Number
CAS 160995-22-2
Target and Pathway
Target(s) Coagulation factor Xa Target Info Modulator [534730]
Coagulation factor IX Target Info Modulator [534730]
KEGG Pathway Complement and coagulation cascadeshsa04610:Complement and coagulation cascades
PANTHER Pathway Blood coagulationP00011:Blood coagulation
Pathway Interaction Database Beta2 integrin cell surface interactions
PathWhiz Pathway CoagulationPW000562:Coagulation
Reactome Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-140834:Extrinsic Pathway of Fibrin Clot Formation
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
Human Complement System
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)WP558:Complement and Coagulation Cascades
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 545778Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004668)
Ref 534730Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule. Biochim Biophys Acta. 1998 Oct 23;1425(2):291-9.

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