TTD | Drug: D0K9KJ

Drug General Information
Drug ID	D0K9KJ
Former ID	DIB019033
Drug Name	BU-E 47
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538730]
Structure		Download 2D MOL
Formula	C21H25ClN6
InChI	InChI=1S/C21H25ClN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27)
InChIKey	ZOROCGHIPADEFK-UHFFFAOYSA-N
PubChem Compound ID	14660352
PubChem Substance ID	32638733, 47510101, 47954498, 103249416, 129932960, 135650029, 163355074, 235085515
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Antagonist	[526569]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
Reactome	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538730	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1219).
Ref 526569	Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. Epub 2003 Mar 6.

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Drug Information