Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K8PH
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| Former ID |
DIB002724
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| Drug Name |
SUVN-504
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| Synonyms |
SUVN-503; SUVN-51005; M1 of SUVN-507, Suven; 5-HT 6 antagonists (emesis), Suven; 5-HT 6 antagonists (obesity), Suven
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| Indication | Emesis [ICD9: 787; ICD10:R11] | Investigative | [1] | ||
| Company |
Suven Life Sciences Ltd
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
O=S(=O)(N1C2CC(C=CC2C=C1)OC)c1ccc(cc1OCC1CCN(CC1)C)Cl
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 6 receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11). | ||||
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