Drug General Information
Drug ID
D0K8NR
Former ID
DCL000425
Drug Name
AMG 386
Drug Type
Small molecular drug
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Phase 3 [523327], [543118]
Company
Amgen
Structure
Download
2D MOL

3D MOL

Formula
Na
Canonical SMILES
[Na]
InChI
1S/Na
InChIKey
KEAYESYHFKHZAL-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Angiopoietin-2 Target Info Modulator [1572591]
Angiopoietin-1 Target Info Modulator [1572591]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
PI3K-Akt signaling pathwayhsa04014:Ras signaling pathway
PI3K-Akt signaling pathway
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
TNFalpha Signaling Pathway
FSH Signaling Pathway
PANTHER Pathway AngiogenesisP00005:Angiogenesis
Pathway Interaction Database Angiopoietin receptor Tie2-mediated signalingangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
SHP2 signaling
Reactome Tie2 SignalingR-HSA-210993:Tie2 Signaling
RAF/MAP kinase cascade
WikiPathways Cell surface interactions at the vascular wallWP1794:Cell surface interactions at the vascular wall
Angiogenesis
References
Ref 523327ClinicalTrials.gov (NCT01281254) TRINOVA-2: Trebananib in Ovarian Cancer-2. U.S. National Institutes of Health.
Ref 543118(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8414).
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.