Drug General Information
Drug ID
D0K6UZ
Former ID
DIB018648
Drug Name
5'-guanidinonaltrindole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539032]
Structure
Download
2D MOL
Formula
C27H29N5O3
InChI
InChI=1S/C27H29N5O3/c28-25(29)30-15-4-5-18-16(10-15)17-11-27(34)20-9-14-3-6-19(33)23-21(14)26(27,24(35-23)22(17)31-18)7-8-32(20)12-13-1-2-13/h3-6,10,13,20,24,31,33-34H,1-2,7-9,11-12H2,(H4,28,29,30)/t20-,24+,26+,27-/m1/s1
InChIKey
VLNHDKDBGWXJEE-GYHUNEDQSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Antagonist [525829]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539032(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1669).
Ref 525829Potent and selective indolomorphinan antagonists of the kappa-opioid receptor. J Med Chem. 2000 Jul 13;43(14):2759-69.

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