Drug Information

Drug General Information
Drug ID
D0K4ZR
Former ID
DIB020600
Drug Name
oleocanthal
Synonyms
(-)-oleocanthal
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541458]
Structure
Download
2D MOL
Formula
C17H20O5
InChI
InChI=1S/C17H20O5/c1-2-14(12-19)15(7-9-18)11-17(21)22-10-8-13-3-5-16(20)6-4-13/h2-6,9,12,15,20H,7-8,10-11H2,1H3/b14-2-/t15-/m0/s1
InChIKey
VPOVFCBNUOUZGG-VAKDEWRISA-N
PubChem Compound ID
11652416
PubChem Substance ID
16755888, 23754345, 76366861, 137272713, 137275743, 140013096, 144073957, 162223022, 163317748, 164160346, 172649903, 178102927, 198981181, 198984607, 226504656, 252109181, 252150010
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily A member 1 Target Info Activator [531340]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 541458(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6308).
Ref 531340Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal. J Neurosci. 2011 Jan 19;31(3):999-1009.

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