Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K4UW
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| Former ID |
DIB014304
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| Drug Name |
Imitrodast
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| Synonyms |
Logran; CS-518; RS-5186
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD10:J45] | Discontinued in Phase 2 | [1] | ||
| Company |
Sankyo Co Ltd
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| Structure |
|
Download2D MOL |
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| Formula |
C13H12N2O2S
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| Canonical SMILES |
c12c(cc(s1)Cn1ccnc1)CCC(=C2)C(=O)[O-].[Na+]
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| CAS Number |
CAS 113817-57-5
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Thromboxane-A synthase | Target Info | Inhibitor | [2] | |
| BioCyc Pathway | C20 prostanoid biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Platelet activation | |||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| Arachidonic acid metabolism | |||||
| Phase 1 - Functionalization of compounds | |||||
| Eicosanoid Synthesis | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000225) | ||||
| REF 2 | RS-5186, a novel thromboxane synthetase inhibitor with a potent and extended duration of action. Thromb Res. 1988 Sep 1;51(5):507-20. | ||||
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