Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K4NZ
|
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| Former ID |
DCL001251
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| Drug Name |
Velneperit
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| Drug Type |
Small molecular drug
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| Indication | Obesity [ICD9: 278; ICD10:E66] | Discontinued in Phase 2 | [1] | ||
| Company |
Shionogi & Co Ltd
|
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| Structure |
|
Download2D MOL |
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| Formula |
C17H24F3N3O3S
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| Canonical SMILES |
CC(C)(C)S(=O)(=O)NC1CCC(CC1)C(=O)NC2=NC=C(C=C2)C(F)(F)F
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| InChI |
1S/C17H24F3N3O3S/c1-16(2,3)27(25,26)23-13-7-4-11(5-8-13)15(24)22-14-9-6-12(10-21-14)17(18,19)20/h6,9-11,13,23H,4-5,7-8H2,1-3H3,(H,21,22,24)
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| InChIKey |
WGEWUYACXPEFPO-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Neuropeptide Y receptor 5 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | New and emerging drug molecules against obesity. J Cardiovasc Pharmacol Ther. 2014 Jan;19(1):65-76. | ||||
| REF 2 | Clinical pipeline report, company report or official report of Shionogi (2011). | ||||
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