Drug Information

Drug General Information
Drug ID
D0K4NZ
Former ID
DCL001251
Drug Name
Velneperit
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Discontinued in Phase 2 [532488]
Company
Shionogi & Co Ltd
Structure
Download
2D MOL

3D MOL
Formula
C17H24F3N3O3S
Canonical SMILES
CC(C)(C)S(=O)(=O)NC1CCC(CC1)C(=O)NC2=NC=C(C=C2)C(F)(F)F
InChI
1S/C17H24F3N3O3S/c1-16(2,3)27(25,26)23-13-7-4-11(5-8-13)15(24)22-14-9-6-12(10-21-14)17(18,19)20/h6,9-11,13,23H,4-5,7-8H2,1-3H3,(H,21,22,24)
InChIKey
WGEWUYACXPEFPO-UHFFFAOYSA-N
PubChem Compound ID
20629114
PubChem Substance ID
33855111, 49694028, 96024719, 135253510, 139857611, 140531241, 140992775, 143039633, 143276930, 160688316, 160859997, 172919827, 198951768, 228882544, 235450128, 235467492, 238204297, 241071036, 243906058, 243991202, 244879739, 246876330
Target and Pathway
Target(s) Neuropeptide Y receptor 5 Target Info Antagonist [551685]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 532488New and emerging drug molecules against obesity. J Cardiovasc Pharmacol Ther. 2014 Jan;19(1):65-76.
Ref 551685Clinical pipeline report, company report or official report of Shionogi (2011).

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