Drug General Information
Drug ID
D0K4GK
Former ID
DIB018533
Drug Name
22R-hydroxycholesterol
Synonyms
22beta-hydroxycholesterol; 22R-OHC
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539787]
Structure
Download
2D MOL
Formula
C27H46O2
InChI
InChI=1S/C27H46O2/c1-17(2)6-11-25(29)18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20-,21-,22+,23-,24-,25+,26-,27+/m0/s1
InChIKey
RZPAXNJLEKLXNO-GFKLAVDKSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Oxysterols receptor LXR-beta Target Info Agonist [534255]
Oxysterols receptor LXR-alpha Target Info Agonist [534255]
Bile acid receptor Target Info Agonist [527938]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis Chsa04976:Bile secretion
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathwayR-HSA-159418:Recycling of bile acids and salts
PPARA activates gene expression
Endogenous sterols
WikiPathways SREBP signalling
Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Farnesoid X Receptor Pathway
Drug Induction of Bile Acid Pathway
References
Ref 539787(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2742).
Ref 527938Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. J Pharmacol Exp Ther. 2006 Apr;317(1):317-25. Epub 2005 Dec 21.
Ref 534255An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996 Oct 24;383(6602):728-31.

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