Drug Information
Drug General Information | |||||
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Drug ID |
D0K4GK
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Former ID |
DIB018533
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Drug Name |
22R-hydroxycholesterol
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Synonyms |
22beta-hydroxycholesterol; 22R-OHC
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539787] | ||
Structure |
Download2D MOL |
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Formula |
C27H46O2
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InChI |
InChI=1S/C27H46O2/c1-17(2)6-11-25(29)18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20-,21-,22+,23-,24-,25+,26-,27+/m0/s1
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InChIKey |
RZPAXNJLEKLXNO-GFKLAVDKSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
7855, 7983970, 10256555, 17501138, 24895852, 46241149, 49688252, 57351298, 75005942, 103114776, 103162244, 103428723, 113461277, 123080470, 126524977, 127346295, 135123118, 135651388, 135764294, 137109197, 139022589, 140154466, 160645367, 162226561, 162817550, 172829375, 179293231, 184582401, 226478367, 242081676
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Target and Pathway | |||||
Target(s) | Oxysterols receptor LXR-beta | Target Info | Agonist | [534255] | |
Oxysterols receptor LXR-alpha | Target Info | Agonist | [534255] | ||
Bile acid receptor | Target Info | Agonist | [527938] | ||
WikiPathways | SREBP signalling | ||||
Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity | |||||
Nuclear Receptors Meta-Pathway | |||||
PPAR Alpha Pathway | |||||
Liver X Receptor Pathway | |||||
Adipogenesis | |||||
SREBF and miR33 in cholesterol and lipid homeostasis | |||||
Farnesoid X Receptor Pathway | |||||
Drug Induction of Bile Acid Pathway | |||||
References | |||||
Ref 527938 | Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. J Pharmacol Exp Ther. 2006 Apr;317(1):317-25. Epub 2005 Dec 21. | ||||
Ref 534255 | An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996 Oct 24;383(6602):728-31. |
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