| Drug General Information |
| Drug ID |
D0K1QS
|
| Former ID |
DNC002827
|
| Drug Name |
Dimethyltryptamine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C12H16N2
|
| InChI |
InChI=1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3
|
| InChIKey |
DMULVCHRPCFFGV-UHFFFAOYSA-N
|
| CAS Number |
CAS 61-50-7
|
| PubChem Compound ID |
|
| PubChem Substance ID |
10500, 110132, 589970, 627611, 5091638, 7980056, 8153806, 10529872, 15265804, 29225098, 46507463, 46530476, 49747346, 49983960, 50909762, 57323178, 58007473, 85209948, 94526579, 99381451, 103172928, 103936452, 104311088, 124954094, 125655143, 126525562, 126552446, 126660419, 126687274, 127757321, 131728744, 134350860, 134971030, 135650188, 137001252, 142148247, 160964744, 162881661, 164840499, 170538817, 179226219, 196397667, 198948879, 223675963, 223978815, 226671707, 244002216, 249781217, 249924405, 252157284
|
| Target and Pathway |
| Target(s) |
Sigma(1)-type opioid receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| 5-hydroxytryptamine 6 receptor |
Target Info |
Inhibitor |
[2]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Serotonergic synapsehsa04020:Calcium signaling pathway
|
|
Gap junction
|
|
Serotonergic synapse
|
|
Inflammatory mediator regulation of TRP channels
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathway
|
|
PathWhiz Pathway
|
Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
|
|
Reactome
|
Serotonin receptors
|
|
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
miR-targeted genes in squamous cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBaseWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
|
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
SIDS Susceptibility Pathways
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR downstream signaling
|
|
GPCRs, Other
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 141). |
|---|
| REF 2 | Dose-response study of N,N-dimethyltryptamine in humans. I. Neuroendocrine, autonomic, and cardiovascular effects. Arch Gen Psychiatry. 1994 Feb;51(2):85-97. |
|---|
