Drug General Information
Drug ID	D0K1DC
Former ID	DIB013719
Drug Name	Romergoline
Synonyms	FCE-23884
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Discontinued in Phase 2	[544873]
Company	Pharmacia & Upjohn AB
Structure		Download 2D MOL 3D MOL
Formula	C20H22N4O2
Canonical SMILES	C12=C[C@H](CN([C@@H]1Cc1c3c2cccc3[nH]c1)C)CN1CC(=O)NC(=<br />O)C1
CAS Number	CAS 107052-56-2
PubChem Compound ID	65898
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Modulator	[551899]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 544873	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001388)
Ref 551899	CA patent application no. 648479, Implants for the treatment of dopamine associated states.

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