Drug Information

Drug General Information
Drug ID
D0JC9N
Former ID
DAP000115
Drug Name
Adapalene
Synonyms
Adaferin; Adapaleno; Adapalenum; Differin; Differine; CD 271; CD271; Adaferin (TN); Adapaleno [INN-Spanish]; Adapalenum [INN-Latin]; CD-271; Differin (TN); Differin, Adapalene; KS-1196; Adapalene [USAN:BAN:INN]; Adapalene (JAN/USAN/INN); 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid; 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid; 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid; 6-[3-(adamantan-1-yl)-4-methoxyphenyl]-2-naphthoic acid
Drug Type
Small molecular drug
Indication Acne vulgaris [ICD9: 706.1; ICD10:L70.0] Approved [536911], [540832]
Therapeutic Class
Dermatologic Agents
Company
Galderma Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C28H28O3
InChI
InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)
InChIKey
LZCDAPDGXCYOEH-UHFFFAOYSA-N
CAS Number
CAS 106685-40-9
PubChem Compound ID
60164
PubChem Substance ID
6822615, 7848175, 8186698, 14757761, 15676959, 26719856, 26758039, 43117595, 46386720, 46505019, 49830264, 50064121, 56394856, 57313991, 80928761, 85174389, 92712347, 93166422, 93815151, 99300517, 99437066, 103390862, 103978806, 104131655, 104320030, 109693041, 117546878, 119525345, 121362199, 124757134, 124893173, 125163938, 125333636, 125536425, 126630117, 126656770, 126666780, 128562074, 131293846, 134337439, 134358633, 135018958, 135653634, 135692088, 135696673, 136375522, 137003094, 142336877, 144115539, 144205789
ChEBI ID
ChEBI:31174
SuperDrug ATC ID
D10AD03
SuperDrug CAS ID
cas=106685409
Target and Pathway
Target(s) Retinoic acid receptor Target Info Binder [535694], [536877]
References
Ref 536911Topical retinoids in acne vulgaris: update on efficacy and safety. Am J Clin Dermatol. 2008;9(6):369-81. doi: 10.2165/0128071-200809060-00003.
Ref 540832(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5429).
Ref 535694Topical treatment in acne: current status and future aspects. Dermatology. 2003;206(1):29-36.
Ref 536877A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008 Nov;43(5):421-4.

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