Drug General Information
Drug ID	D0J8RM
Former ID	DIB016300
Drug Name	Posatirelin
Synonyms	Esotirelin; Pyladox; RGH-2202
Drug Type	Small molecular drug
Indication	Neurodegenerative disease [ICD9: 330-337; ICD10:G30-G32]		Discontinued in Phase 3	[545969]
Company	Gedeon Richter Ltd
Structure		Download 2D MOL 3D MOL
Formula	C17H28N4O4
Canonical SMILES	N1(C(=O)[C@@H](NC(=O)[C@H]2NC(=O)CCC2)CC(C)C)[C@H](C(=O<br />)N)CCC1
CAS Number	CAS 78664-73-0
PubChem Compound ID	71230
Target and Pathway
Target(s)	Thyrotropin-releasing hormone receptor	Target Info	Modulator	[526454]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Thyrotropin-releasing hormone receptor signaling pathway
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545969	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005568)
Ref 526454	TRH analogs at Gedeon Richter Ltd.: highlights of experimental and clinical efficacy of posatirelin. Acta Pharm Hung. 2002;72(1):62-8.

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