Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0J8LD
|
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| Former ID |
DNC001308
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| Drug Name |
SCH58261
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C18H15N7O
|
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| InChI |
InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
|
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| InChIKey |
UTLPKQYUXOEJIL-UHFFFAOYSA-N
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| CAS Number |
CAS 160098-96-4
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7980583, 10258377, 14900558, 26753254, 33500024, 47510090, 47731275, 50068074, 57395307, 76160696, 85209294, 85286114, 85788185, 90341001, 91746416, 99431535, 103180831, 103978930, 104425548, 121362004, 126671705, 129418187, 134339148, 134340512, 134341517, 135153621, 135651030, 135651205, 135697574, 142362474, 144240144, 144240145, 162023190, 162223707, 163124439, 163565213, 164759434, 170474553, 175612758, 176225385, 179294000, 184538735, 196376772, 198945991, 202558330, 204360450, 215780619, 223454701, 223519245, 223660679
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| Target and Pathway | |||||
| Target(s) | Adenosine A2a receptor | Target Info | Antagonist | [2], [3] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| Calcium signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Vascular smooth muscle contraction | |||||
| Parkinson's disease | |||||
| Alcoholism | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| PathWhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | ||||
| Reactome | NGF-independant TRKA activation | ||||
| Adenosine P1 receptors | |||||
| G alpha (s) signalling events | |||||
| Surfactant metabolism | |||||
| WikiPathways | Nucleotide GPCRs | ||||
| Monoamine Transport | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| NGF signalling via TRKA from the plasma membrane | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 403). | ||||
| REF 2 | Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice. Br J Pharmacol. 2001 Sep;134(1):68-77. | ||||
| REF 3 | Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia. 2003 Aug;43(2):190-4. | ||||
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