Drug Information

Drug General Information
Drug ID
D0J8JP
Former ID
DCL000930
Drug Name
Pimavanserin
Synonyms
ST51054136; AC-5273; I14-1981; 1-[(4-fluorophenyl)methyl]-1-(1-methyl-4-piperidyl)-3-[[4-(2-methylpropoxy)phenyl]methyl]urea
Drug Type
Small molecular drug
Indication Parkinson disease psychosis [ICD10:G00-G99] Approved [889440]
Parkinson's disease; Psychosis; Schizophrenia [ICD9: 290-299, 332, 295; ICD10:F02.3, F20-F29, G20, F20] Phase 3 [543125], [547301]
Company
Acadia Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C25H34FN3O2
InChI
InChI=1S/C25H34FN3O2/c1-19(2)18-31-24-10-6-20(7-11-24)16-27-25(30)29(23-12-14-28(3)15-13-23)17-21-4-8-22(26)9-5-21/h4-11,19,23H,12-18H2,1-3H3,(H,27,30)
InChIKey
RKEWSXXUOLRFBX-UHFFFAOYSA-N
CAS Number
CAS 706779-91-1
PubChem Compound ID
10071196
PubChem Substance ID
15056570, 22487415, 44188211, 78486719, 85246183, 92721414, 118844935, 125356530, 126619173, 126661719, 131324331, 134222314, 134339374, 135262066, 135263922, 137005043, 137354663, 152042012, 162104969, 162205223, 163242432, 163884831, 172914648, 174539041, 187072850, 198956315, 210275101, 210280740, 223435110, 223679488, 224220742, 226970761, 241139662, 242550037, 248856106, 249870692, 252166633, 252216077, 252448725
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Modulator
Atypical antipsychotic Target Info Modulator [889440]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543125(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8423).
Ref 547301Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014997)
Ref 8894402016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.
Ref 8894402016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.

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