Drug General Information
Drug ID	D0J5QW
Former ID	DIB006567
Drug Name	ON-579
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Terminated	[545526]
Company	Taisho Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C16H14ClF2NO5S2
Canonical SMILES	S(=O)(=O)(c1ccc(cc1)Cl)NCCSc1cc(c(c(c1)F)OCC(=O)O)F
CAS Number	CAS 141286-14-8
PubChem Compound ID	192308
Target and Pathway
Target(s)	Thromboxane A2 receptor	Target Info	Modulator	[533593]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	Prostanoid ligand receptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
	Thromboxane signalling through TP receptor
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545526	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003601)
Ref 533593	The effect of a TXA2 receptor antagonist ON-579 on experimental allergic reactions. Prostaglandins Leukot Essent Fatty Acids. 1995 Aug;53(2):123-33.

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