| Drug General Information |
| Drug ID |
D0J3EZ
|
| Former ID |
DNC012250
|
| Drug Name |
6-Nitro-1,4-dihydro-quinoxaline-2,3-dione
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H5N3O4
|
| Canonical SMILES |
C1=CC2=C(C=C1[N+](=O)[O-])NC(=O)C(=O)N2
|
| InChI |
1S/C8H5N3O4/c12-7-8(13)10-6-3-4(11(14)15)1-2-5(6)9-7/h1-3H,(H,9,12)(H,10,13)
|
| InChIKey |
RYMLSFWVYNAKAR-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Inhibitor |
[1]
|
|---|
| Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[1]
|
| NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
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Calcium signaling pathway
|
|
cAMP signaling pathway
|
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Neuroactive ligand-receptor interaction
|
|
Circadian entrainment
|
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Long-term potentiation
|
|
Glutamatergic synapse
|
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Dopaminergic synapse
|
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Alzheimer's disease
|
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Amyotrophic lateral sclerosis (ALS)
|
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Cocaine addiction
|
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Amphetamine addiction
|
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Nicotine addiction
|
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Alcoholism
|
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Systemic lupus erythematosushsa04014:Ras signaling pathway
|
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Huntington's disease
|
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PANTHER Pathway
|
Huntington disease
|
|
Ionotropic glutamate receptor pathway
|
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
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Pathway Interaction Database
|
Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
|
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Reelin signaling pathway
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|
Reactome
|
Unblocking of NMDA receptor, glutamate binding and activation
|
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CREB phosphorylation through the activation of CaMKII
|
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Ras activation uopn Ca2+ infux through NMDA receptor
|
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RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
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RAF/MAP kinase cascade
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WikiPathways
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Hypothetical Network for Drug Addiction
|
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
|
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BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
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Spinal Cord Injury
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BDNF signaling pathway
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Alzheimers Disease
|
| References |
| REF 1 | J Med Chem. 1997 Oct 24;40(22):3679-86.5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors. |
|---|
