Drug Information

Drug General Information
Drug ID
D0J2KV
Former ID
DAP000497
Drug Name
Propafenone
Synonyms
Propafenona; Propafenonum; Rythmol; Propafenon Hexal; Propafenon hexal (TN); Propafenona [INN-Spanish]; Propafenone (INN); Propafenone [INN:BAN]; Propafenone-HCl; Propafenonum [INN-Latin]; Rythmol SR (TN); Rytmonorm (TN); 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone; 1-(2-(2-Hydroxy-3-propylaminopropoxy)phenyl)-3-phenylpropan-1-one; 1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride; 1-[2-(2-Hydroxy-3-[propylamino]-propoxy)phenyl]-3-phenyl-1-propanone; 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
Drug Type
Small molecular drug
Indication Tachyarrhythmias [ICD9: 427, 785.0; ICD10:I47-I49, R00.0] Approved [536095], [539655]
Therapeutic Class
Antiarrhythmic Agents
Company
Reliant Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C21H27NO3
InChI
InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3
InChIKey
JWHAUXFOSRPERK-UHFFFAOYSA-N
CAS Number
CAS 54063-53-5
PubChem Compound ID
4932
PubChem Substance ID
9585, 5363963, 8153039, 11336081, 11361320, 11364506, 11367068, 11369630, 11373069, 11373956, 11377792, 11462292, 11466527, 11467647, 11485341, 11486054, 11489419, 11491720, 11492024, 11495426, 14900354, 24278636, 26752315, 26752316, 29224010, 46504529, 47291199, 47291200, 47440332, 47440333, 47589059, 47736554, 47810815, 47959826, 48035202, 48035203, 49698950, 50024038, 50105251, 50105252, 57322533, 74963632, 85088939, 85788247, 85788874, 90341088, 92308765, 92309881, 96025121, 99300795
SuperDrug ATC ID
C01BC03
SuperDrug CAS ID
cas=054063535
Target and Pathway
Target(s) E3 ubiquitin protein ligase COP1 Target Info Modulator [556264]
KEGG Pathway p53 signaling pathway
Ubiquitin mediated proteolysis
PANTHER Pathway P53 pathway feedback loops 1
Pathway Interaction Database ATM pathway
Direct p53 effectors
p53 pathway
References
Ref 536095New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22.
Ref 539655(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2561).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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