Drug Information
Drug General Information | |||||
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Drug ID |
D0J1OJ
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Former ID |
DNCL003416
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Drug Name |
Nintedanib
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Drug Type |
Small molecular drug
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Company |
Boehringer Ingelheim
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Structure |
Download2D MOL |
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Formula |
C31H33N5O4
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InChI |
InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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InChIKey |
XZXHXSATPCNXJR-ZIADKAODSA-N
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CAS Number |
CAS 656247-17-5
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PubChem Compound ID | |||||
PubChem Substance ID |
14836969, 24116377, 44845702, 56435863, 76307381, 99431587, 99432362, 103654502, 109693020, 124343350, 124756932, 125163739, 126583666, 126724182, 131465103, 134964383, 135264167, 135267499, 136340157, 136920292, 139351111, 143498980, 144115708, 152236441, 152258852, 152344119, 160647702, 162011437, 162037383, 162202550, 162205188, 164041723, 172232574, 174531531, 174561006, 177748905, 178102559, 180386833, 188899496, 198986794, 223388548, 223471427, 223685460, 223704774, 223896861, 226755113, 226755114, 249738349, 249807126, 251963000
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Target and Pathway | |||||
Target(s) | Triple angiokinase | Target Info | Inhibitor | [533123] | |
Vascular endothelial growth factor receptor 1 | Target Info | Modulator | [533123] | ||
Basic fibroblast growth factor receptor 1 | Target Info | Modulator | [533123] | ||
Anti-fibrotic kinase | Target Info | Inhibitor | [533123] | ||
Platelet-derived growth factor receptor | Target Info | Modulator | [533123] | ||
KEGG Pathway | Ras signaling pathway | ||||
Rap1 signaling pathway | |||||
Cytokine-cytokine receptor interaction | |||||
HIF-1 signaling pathway | |||||
Endocytosis | |||||
PI3K-Akt signaling pathway | |||||
Focal adhesion | |||||
Transcriptional misregulation in cancer | |||||
Rheumatoid arthritishsa04010:MAPK signaling pathway | |||||
Adherens junction | |||||
Signaling pathways regulating pluripotency of stem cells | |||||
Regulation of actin cytoskeleton | |||||
Pathways in cancer | |||||
Proteoglycans in cancer | |||||
Prostate cancer | |||||
Melanoma | |||||
Central carbon metabolism in cancer | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | Angiogenesis | ||||
FGF signaling pathway | |||||
Pathway Interaction Database | Glypican 1 network | ||||
HIF-2-alpha transcription factor network | |||||
S1P3 pathway | |||||
VEGF and VEGFR signaling network | |||||
VEGFR1 specific signals | |||||
Signaling events mediated by VEGFR1 and VEGFR2glypican_1pathway:Glypican 1 network | |||||
Syndecan-4-mediated signaling events | |||||
N-cadherin signaling events | |||||
FGF signaling pathway | |||||
WikiPathways | Focal Adhesion | ||||
Signaling by VEGF | |||||
AngiogenesisWP51:Regulation of Actin Cytoskeleton | |||||
Endochondral Ossification | |||||
MAPK Signaling Pathway | |||||
Mesodermal Commitment Pathway | |||||
Hair Follicle Development: Induction (Part 1 of 3) | |||||
Integrated Pancreatic Cancer Pathway | |||||
Signaling Pathways in Glioblastoma | |||||
Neural Crest Differentiation | |||||
Signaling by FGFR | |||||
References | |||||
Ref 523930 | ClinicalTrials.gov (NCT01610869) Low Dose Cyclophosphamide +/-- Nintedanib in Advanced Ovarian Cancer. U.S. National Institutes of Health. | ||||
Ref 524516 | ClinicalTrials.gov (NCT01979952) Nintedanib Twice Daily vs Placebo in Patients Diagnosed With Idiopathic Pulmonary Fibrosis (IPF). U.S. National Institutes of Health. | ||||
Ref 524899 | ClinicalTrials.gov (NCT02231164) LUME-Columbus: Nintedanib Plus Docetaxel in Advanced Non-small Cell Lung Cancer With Translational Research. U.S. National Institutes of Health. | ||||
Ref 541221 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5936). | ||||
Ref 556264 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. |
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