Drug Information

Drug General Information
Drug ID
D0J1CL
Former ID
DIB016222
Drug Name
EcoNail
Synonyms
Econazole/SEPA
Drug Type
Small molecular drug
Indication Fungal infections [ICD9: 110-118; ICD10:B35-B49] Phase 2 [521897]
Company
MacroChem Corporation
Structure
Download
2D MOL

3D MOL
Formula
C18H16Cl3N3O4
Canonical SMILES
C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl.[N+](<br />=O)(O)[O-]
InChI
1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
InChIKey
DDXORDQKGIZAME-UHFFFAOYSA-N
PubChem Compound ID
68589
PubChem Substance ID
10269, 568319, 855519, 7847945, 8149766, 8192218, 10321291, 14783868, 17389020, 24894567, 26612223, 26680768, 26748545, 26748546, 43125140, 48423366, 48425108, 49855200, 50065074, 50107428, 50107429, 50350473, 56422230, 57316950, 81043837, 83613425, 85085771, 85174214, 85273736, 85273879, 91011492, 92124547, 92125234, 92307733, 93619671, 99301201, 99351147, 103771032, 103913771, 104342547, 121362905, 124360763, 124636808, 124757863, 124766327, 124801105, 125164667, 125345818, 126630914, 126657434
Target and Pathway
Target(s) Fungal Cytochrome P450 51 Target Info Inhibitor [531032]
References
Ref 521897ClinicalTrials.gov (NCT00385502) A Trial of the Safety and Efficacy of EcoNail in the Treatment of Fungus Infections of the Great Toenail. U.S. National Institutes of Health.
Ref 531032Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45.

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