Drug Information

Drug General Information
Drug ID
D0IT5D
Former ID
DIB018826
Drug Name
alpha-propyldopacetamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468156]
Structure
Download
2D MOL
Formula
C11H15NO3
InChI
InChI=1S/C11H15NO3/c1-2-3-8(11(12)15)7-4-5-9(13)10(14)6-7/h4-6,8,13-14H,2-3H2,1H3,(H2,12,15)
InChIKey
GDXQWRJYXZXWMT-UHFFFAOYSA-N
PubChem Compound ID
101635
PubChem Substance ID
3136465, 6666849, 10232150, 15067891, 44431637, 79767903, 95613356, 99343801, 103811726, 104364811, 117568991, 124582944, 125680743, 135057891, 162377975, 162377976, 163141304, 164815647, 165437838, 178101788, 184560818, 241203964, 250000097
Target and Pathway
Target(s) Tyrosine 3-monooxygenase Target Info Inhibitor [543389]
Tryptophan 5-hydroxylase-1 Target Info Inhibitor [543387]
L-Tryptophan hydroxylase 2 Target Info Inhibitor [543388]
BioCyc Pathway Catecholamine biosynthesisPWY66-401:Superpathway of tryptophan utilization
Serotonin and melatonin biosynthesis
KEGG Pathway Tyrosine metabolism
Metabolic pathways
Dopaminergic synapse
Prolactin signaling pathway
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholismhsa00380:Tryptophan metabolism
Serotonergic synapse
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP04371:5-Hydroxytryptamine biosynthesis
Pathway Interaction Database ATF-2 transcription factor network
AP-1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Alpha-synuclein signaling
PathWhiz Pathway Catecholamine BiosynthesisPW000163:Tryptophan Metabolism
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Dopaminergic Neurogenesis
Metabolism of amino acids and derivatives
Dopamine metabolism
Parkinsons Disease Pathway
Nicotine Activity on Dopaminergic NeuronsWP706:SIDS Susceptibility Pathways
Tryptophan metabolism
References
Ref 468156(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5095).
Ref 543387(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241).
Ref 543388(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1242).
Ref 543389(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).

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