Drug General Information
Drug ID
D0I9NH
Former ID
DNC006482
Drug Name
5-hydroxy-2-(4-aminophenyl)benzofuran
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528159]
Structure
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2D MOL

3D MOL

Formula
C14H11NO2
Canonical SMILES
C1=CC(=CC=C1C2=CC3=C(O2)C=CC(=C3)O)N
InChI
1S/C14H11NO2/c15-11-3-1-9(2-4-11)14-8-10-7-12(16)5-6-13(10)17-14/h1-8,16H,15H2
InChIKey
JDGXRZSZWVUFMN-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Amyloid beta A4 protein Target Info Inhibitor [528159]
KEGG Pathway Notch signaling pathway
Alzheimer's disease
Reactome Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
EPH-ephrin mediated repulsion of cells
WikiPathways Notch Signaling Pathway
Signaling by ERBB4
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Signaling by NOTCH2
Notch Signaling Pathway
Alzheimers Disease
Signalling by NGF
References
Ref 528159J Med Chem. 2006 May 4;49(9):2725-30.Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.
Ref 528159J Med Chem. 2006 May 4;49(9):2725-30.Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.

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