Drug General Information
Drug ID	D0I9HG
Former ID	DIB007345
Drug Name	Amsilarotene
Synonyms	Am-555S; TAC-101; Anticancer retinoic acid receptor antagonist (oral), Taiho
Drug Type	Small molecular drug
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Phase 2	[522335]
Company	Taiho Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C20H27NO3Si2
Canonical SMILES	C(=O)(c1cc(cc(c1)[Si](C)(C)C)[Si](C)(C)C)Nc1ccc(C(=O)O)<br />cc1
CAS Number	CAS 125973-56-0
PubChem Compound ID	9800306
Target and Pathway
Target(s)	Retinoic acid receptor	Target Info	Antagonist	[526402]
References
Ref 522335	ClinicalTrials.gov (NCT00687596) Study of TAC-101 as Second Line Treatment in Patients With Advanced Hepatocellular Carcinoma Who Received Sorafenib as First Line Therapy. U.S. National Institutes ofHealth.
Ref 526402	Initial clinical trial of oral TAC-101, a novel retinoic acid receptor-alpha selective retinoid, in patients with advanced cancer. J Clin Oncol. 2002 Aug 15;20(16):3522-32.

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