Drug Information

Drug General Information
Drug ID
D0I9DN
Former ID
DNC000785
Drug Name
IL-4R
Indication Discovery agent Phase 2 [521488]
Target and Pathway
Target(s) Interleukin-4 Target Info Inhibitor [535189]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Intestinal immune network for IgA production
Leishmaniasis
Measles
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease (IBD)
Allograft rejection
NetPath Pathway TCR Signaling Pathway
TSLP Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database Notch signaling pathway
IL4-mediated signaling events
CD40/CD40L signaling
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
AP-1 transcription factor network
IL2 signaling events mediated by STAT5
Calcium signaling in the CD4+ TCR pathway
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
WikiPathways Cytokines and Inflammatory Response
Inflammatory Response Pathway
IL-4 Signaling Pathway
Spinal Cord Injury
Allograft Rejection
Folate Metabolism
References
Ref 521488ClinicalTrials.gov (NCT00017693) Recombinant Human IL-4 Receptor Used in Treatment of Asthma. U.S. National Institutes of Health.
Ref 535189Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol. 2001 Jun;107(6):963-70.

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