Drug Information

Drug General Information
Drug ID
D0I9AT
Former ID
DIB021092
Drug Name
tryptanthrin
Synonyms
GNF-PF-2691; couroupitine a
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532500]
Structure
Download
2D MOL
Formula
C15H8N2O2
InChI
InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H
InChIKey
VQQVWGVXDIPORV-UHFFFAOYSA-N
PubChem Compound ID
73549
PubChem Substance ID
12925, 463068, 606847, 872097, 4453145, 8195762, 11407505, 15196648, 24823948, 26754607, 43129468, 47737193, 50110078, 50354465, 53837731, 57319147, 57727906, 81092989, 85090210, 85860316, 90460831, 103274177, 103850092, 104098377, 104355519, 105218556, 117357400, 124548921, 124813199, 129513211, 131334994, 135033181, 137171547, 142307813, 160836366, 162091701, 163305319, 163399256, 164235665, 170179247, 172904085, 175607820, 184573636, 186011300, 204370956, 223251841, 223441148, 223454999, 223485542, 223519501
Target and Pathway
Target(s) Indoleamine 2,3-dioxygenase Target Info Inhibitor [532500]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
African trypanosomiasis
NetPath Pathway TSLP Signaling Pathway
IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 532500Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31.
Ref 532500Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.