Drug General Information
Drug ID
D0I6UU
Former ID
DIB003540
Drug Name
UK-74505
Drug Type
Small molecular drug
Indication Septic shock [ICD9: 785.52; ICD10:A41.9] Discontinued in Phase 2 [544958]
Company
Pfizer Ltd
Structure
Download
2D MOL

3D MOL

Formula
C34H29ClN6O3
Canonical SMILES
C1(=C(NC(=C(C1c1c(Cl)cccc1)C(=O)Nc1ncccc1)C)c1ccc(n2c(n<br />c3c2ccnc3)C)cc1)C(=O)OCC
CAS Number
CAS 122956-68-7
PubChem Compound ID
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [533761]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 544958Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001719)
Ref 533761Differential effects of the PAF receptor antagonist UK-74,505 on neutrophil and eosinophil accumulation in guinea-pig skin. Br J Pharmacol. 1994 Oct;113(2):513-21.

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