Drug General Information
Drug ID
D0I5UU
Former ID
DNC001035
Drug Name
Norastemizole
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Preregistration [546280]
Structure
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2D MOL

3D MOL

Formula
C19H21FN4
Canonical SMILES
C1CNCCC1NC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F
InChI
1S/C19H21FN4/c20-15-7-5-14(6-8-15)13-24-18-4-2-1-3-17(18)23-19(24)22-16-9-11-21-12-10-16/h1-8,16,21H,9-13H2,(H,22,23)
InChIKey
SFOVDSLXFUGAIV-UHFFFAOYSA-N
CAS Number
CAS 75970-64-8
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Histamine H1 receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 546280Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007228)

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