Drug Information

Drug General Information
Drug ID
D0I5HF
Former ID
DCL000438
Drug Name
Apixaban
Synonyms
GG2; BMS 562247-01; BMS-562247; Eliquis (TN); BMS-562247-01; Apixaban (JAN/USAN/INN); BMS-562247-01, Apixaban; Ro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahyd
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Approved [532210], [541527]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C25H25N5O4
InChI
InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
InChIKey
QNZCBYKSOIHPEH-UHFFFAOYSA-N
CAS Number
CAS 503612-47-3
PubChem Compound ID
10182969
PubChem Substance ID
15178464, 17397366, 22578033, 26736936, 40272539, 46519072, 51992439, 53812906, 56310620, 57374335, 99375349, 99444299, 103535612, 104253239, 109693404, 124757362, 124772059, 125164166, 125433570, 126644898, 126665798, 134339057, 135252374, 135727449, 135727826, 136367462, 136368094, 136920385, 137183704, 139455355, 144115617, 152258806, 152343992, 152344098, 160647657, 160874191, 160962913, 160968889, 162011738, 163884621, 164194092, 164777207, 165247616, 170497908, 172912849, 174006823, 174549337, 175266926, 175427077, 178103006
SuperDrug ATC ID
B01AF02
Target and Pathway
Target(s) Coagulation factor Xa Target Info Inhibitor [549835], [549974]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Blood coagulation
Pathway Interaction Database Beta2 integrin cell surface interactions
PathWhiz Pathway Coagulation
Reactome Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
Human Complement System
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 541527(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6390).
Ref 549835Effects of the oral, direct factor Xa inhibitor apixaban on routine coagulation assays and anti-FXa assays. J Thromb Haemost. 2014 Sep;12(9):1545-53.
Ref 549974Pfizer. Product Development Pipeline. March 31 2009.

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