Drug Information

Drug General Information
Drug ID
D0I4DQ
Former ID
DAP000359
Drug Name
Alprostadil
Synonyms
Alista; Alprostadilum; Befar; Caverject; Edex; FemLife; Femprox; Muse; Prink; Prostavasin; RayVa; Sugiran; Topiglan; Viridal; Vitaros; Prostin VR; Prostin VR Pediatric; Alprostadil Prostoglandin E1; MR 256; PGE1; PGE1 Oligomer; Prostaglandin E1; Alprox-TD; BML1-F06; Befar (TN); Caverject (TN); Edex (TN); HEI-507; L-Prostaglandin E1; MR-256; Muse (TN); Prink (TN); Prostin VR pediatric (TN); U-10136; Alprostadil (JP15/USP/INN); Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11alpha,13E,15S)-, homopolymer; (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid; (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid; (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate; (13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-oic acid; 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
Drug Type
Small molecular drug
Indication Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4] Approved [536500], [539183]
Therapeutic Class
Vasodilator Agents
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C20H34O5
InChI
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
InChIKey
GMVPRGQOIOIIMI-DWKJAMRDSA-N
CAS Number
CAS 745-65-3
PubChem Compound ID
5280723
PubChem Substance ID
7312, 3139926, 4266050, 7847248, 7978676, 8143220, 8616376, 12013405, 14901054, 14901056, 24887977, 24890439, 24898661, 24898855, 24898994, 26719695, 26752225, 26752226, 39289772, 46386879, 46386882, 46387002, 47216549, 47515087, 47515088, 47810514, 47959471, 48110217, 48184750, 48415538, 49681576, 49699251, 50104916, 50104917, 53790811, 57357853, 57654538, 77812073, 85789478, 91702047, 92126041, 92308647, 92309224, 92309904, 92712130, 93166905, 99300818, 99302336, 103171219, 103914567
ChEBI ID
ChEBI:15544
SuperDrug ATC ID
C01EA01; G04BE01
SuperDrug CAS ID
cas=000745653
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Modulator [534906]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 536500Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin Emerg Drugs. 2007 Sep;12(3):461-77.
Ref 539183(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1882).
Ref 534906Flow after prostaglandin E1 is mediated by receptor-coupled adenylyl cyclase in human anterior segments. Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2622-6.

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