Drug General Information
Drug ID
D0I3XA
Former ID
DNC002338
Drug Name
Ciproxifan
Drug Type
Small molecular drug
Indication Dementia; Obesity [ICD9: 290-294, 278; ICD10:F01-F07, E66] Investigative [538780]
Structure
Download
2D MOL

3D MOL

Formula
C16H18N2O2
InChI
InChI=1S/C16H18N2O2/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14/h5-8,10-12H,1-4,9H2,(H,17,18)
InChIKey
ACQBHJXEAYTHCY-UHFFFAOYSA-N
CAS Number
CAS 184025-19-2
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Alpha-2A adrenergic receptor Target Info Antagonist [536039]
5-Hydroxytryptamine 3 receptor Target Info Antagonist [536039]
Histamine H3 receptor Target Info Antagonist [536039]
Alpha-2C adrenergic receptor Target Info Antagonist [536039]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390650:Histamine receptors
G alpha (i) signalling eventsR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 538780(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1265).
Ref 536039The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.

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