| Drug General Information |
| Drug ID |
D0I1FJ
|
| Former ID |
DNC005279
|
| Drug Name |
SB-747651A
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H22N8O
|
| InChI |
InChI=1S/C16H22N8O/c1-2-24-14-10(8-20-11-3-5-18-6-4-11)7-19-9-12(14)21-16(24)13-15(17)23-25-22-13/h7,9,11,18,20H,2-6,8H2,1H3,(H2,17,23)
|
| InChIKey |
MBCJUIJWPYUEBX-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
16488471, 23544804, 42472886, 56374140, 80836789, 103456913, 134342484, 141487286, 142852062, 174007095, 180394056, 223965123, 230620949, 243476798, 249565810
|
| Target and Pathway |
| Target(s) |
mRNA of AkT-3 |
Target Info |
Inhibitor |
[2]
|
|---|
| Rho-associated protein kinase 1 |
Target Info |
Inhibitor |
[2]
|
| Ribosomal protein S6 kinase |
Target Info |
Inhibitor |
[3]
|
| RAC serine/threonine-protein kinase |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
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MAPK signaling pathway
|
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ErbB signaling pathway
|
|
Ras signaling pathway
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Rap1 signaling pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
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HIF-1 signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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mTOR signaling pathway
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PI3K-Akt signaling pathway
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AMPK signaling pathway
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Apoptosis
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Adrenergic signaling in cardiomyocytes
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VEGF signaling pathway
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Osteoclast differentiation
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Focal adhesion
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Tight junction
|
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Signaling pathways regulating pluripotency of stem cells
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Platelet activation
|
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Toll-like receptor signaling pathway
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Jak-STAT signaling pathway
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|
T cell receptor signaling pathway
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B cell receptor signaling pathway
|
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Fc epsilon RI signaling pathway
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Fc gamma R-mediated phagocytosis
|
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TNF signaling pathway
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Neurotrophin signaling pathway
|
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Cholinergic synapse
|
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Dopaminergic synapse
|
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Insulin signaling pathway
|
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Progesterone-mediated oocyte maturation
|
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Estrogen signaling pathway
|
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Prolactin signaling pathway
|
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Thyroid hormone signaling pathway
|
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Adipocytokine signaling pathway
|
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Glucagon signaling pathway
|
|
Regulation of lipolysis in adipocytes
|
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Non-alcoholic fatty liver disease (NAFLD)
|
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Carbohydrate digestion and absorption
|
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
|
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Tuberculosis
|
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Hepatitis C
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Hepatitis B
|
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Measles
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Influenza A
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HTLV-I infection
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Epstein-Barr virus infection
|
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Pathways in cancer
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Proteoglycans in cancer
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Colorectal cancer
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Renal cell carcinoma
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Pancreatic cancer
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Endometrial cancer
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Glioma
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Prostate cancer
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Melanoma
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Chronic myeloid leukemia
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Acute myeloid leukemia
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Small cell lung cancer
|
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Non-small cell lung cancer
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Central carbon metabolism in cancer
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Choline metabolism in cancerhsa04022:cGMP-PKG signaling pathway
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Vascular smooth muscle contraction
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TGF-beta signaling pathway
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Axon guidance
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Leukocyte transendothelial migration
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Regulation of actin cytoskeleton
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Oxytocin signaling pathway
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Pathogenic Escherichia coli infection
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Shigellosis
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Salmonella infection
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MicroRNAs in cancerhsa04012:ErbB signaling pathway
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Choline metabolism in cancerhsa04010:MAPK signaling pathway
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Choline metabolism in cancer
|
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NetPath Pathway
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TSH Signaling Pathway
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IL2 Signaling PathwayNetPath_23:TSH Signaling Pathway
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PANTHER Pathway
|
Angiogenesis
|
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Apoptosis signaling pathway
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EGF receptor signaling pathway
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Endothelin signaling pathway
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FGF signaling pathway
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Huntington disease
|
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Hypoxia response via HIF activation
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Inflammation mediated by chemokine and cytokine signaling pathway
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Interleukin signaling pathway
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PI3 kinase pathway
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T cell activation
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p53 pathway
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Ras Pathway
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p53 pathway by glucose deprivation
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p53 pathway feedback loops 2P00016:Cytoskeletal regulation by Rho GTPase
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CCKR signaling map STP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
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PDGF signaling pathway
|
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CCKR signaling map STP00005:Angiogenesis
|
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Insulin/IGF pathway-protein kinase B signaling cascade
|
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VEGF signaling pathway
|
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p53 pathway feedback loops 2
|
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CCKR signaling map ST
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Pathway Interaction Database
|
S1P3 pathway
|
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Class I PI3K signaling events mediated by Aktprlsignalingeventspathway:Signaling events mediated by PRL
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RhoA signaling pathway
|
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Noncanonical Wnt signaling pathway
|
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EPHB forward signaling
|
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Thromboxane A2 receptor signaling
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PAR4-mediated thrombin signaling events
|
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amb2 Integrin signaling
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Integrins in angiogenesis
|
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EPHA forward signaling
|
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Stabilization and expansion of the E-cadherin adherens junction
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Signaling events mediated by VEGFR1 and VEGFR2
|
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PAR1-mediated thrombin signaling events
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N-cadherin signaling eventsinsulin_pathway:Insulin Pathway
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IL4-mediated signaling events
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CDC42 signaling events
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Angiopoietin receptor Tie2-mediated signaling
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Regulation of Telomerase
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mTOR signaling pathway
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IGF1 pathway
|
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IL2 signaling events mediated by PI3K
|
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RXR and RAR heterodimerization with other nuclear receptor
|
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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a6b1 and a6b4 Integrin signaling
|
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TGF-beta receptor signalingsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
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Fc-epsilon receptor I signaling in mast cells
|
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Endothelins
|
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BCR signaling pathway
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LPA receptor mediated events
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Insulin Pathway
|
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TCR signaling in naï
|
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Plasma membrane estrogen receptor signaling
|
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CD40/CD40L signaling
|
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
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Signaling events mediated by PTP1B
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Coregulation of Androgen receptor activity
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Reelin signaling pathway
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Integrin-linked kinase signaling
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TCR signaling in naï
|
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FAS (CD95) signaling pathway
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FOXA2 and FOXA3 transcription factor networks
|
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Glucocorticoid receptor regulatory network
|
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CXCR4-mediated signaling events
|
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FoxO family signaling
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Ceramide signaling pathway
|
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p75(NTR)-mediated signaling
|
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E-cadherin signaling in the nascent adherens junction
|
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IFN-gamma pathway
|
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ErbB1 downstream signaling
|
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ErbB2/ErbB3 signaling events
|
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IL6-mediated signaling events
|
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E-cadherin signaling in keratinocytes
|
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Nephrin/Neph1 signaling in the kidney podocyte
|
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Retinoic acid receptors-mediated signaling
|
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IL8- and CXCR2-mediated signaling events
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Signaling events mediated by the Hedgehog family
|
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Nongenotropic Androgen signaling
|
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Hedgehog signaling events mediated by Gli proteins
|
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Caspase Cascade in Apoptosis
|
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CXCR3-mediated signaling events
|
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VEGFR1 specific signals
|
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Aurora A signaling
|
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Insulin-mediated glucose transport
|
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Class I PI3K signaling events mediated by Akt
|
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IL8- and CXCR1-mediated signaling events
|
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HIF-1-alpha transcription factor network
|
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p53 pathway
|
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Trk receptor signaling mediated by PI3K and PLC-gamma
|
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VEGFR3 signaling in lymphatic endothelium
|
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FGF signaling pathway
|
|
PathWhiz Pathway
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Leucine Stimulation on Insulin SignalingPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
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Fc Epsilon Receptor I Signaling in Mast Cells
|
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Insulin Signalling
|
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Leucine Stimulation on Insulin Signaling
|
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Reactome
|
Activation of BAD and translocation to mitochondria
|
|
GPVI-mediated activation cascade
|
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PIP3 activates AKT signaling
|
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AKT phosphorylates targets in the cytosol
|
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AKT phosphorylates targets in the nucleus
|
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Negative regulation of the PI3K/AKT network
|
|
AKT-mediated inactivation of FOXO1A
|
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CD28 dependent PI3K/Akt signaling
|
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CTLA4 inhibitory signaling
|
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G beta:gamma signalling through PI3Kgamma
|
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VEGFR2 mediated vascular permeability
|
|
TP53 Regulates Metabolic Genes
|
|
Constitutive Signaling by AKT1 E17K in CancerR-HSA-111465:Apoptotic cleavage of cellular proteins
|
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EPHB-mediated forward signaling
|
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EPHA-mediated growth cone collapse
|
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G alpha (12/13) signalling events
|
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Sema4D induced cell migration and growth-cone collapse
|
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VEGFA-VEGFR2 Pathway
|
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RHO GTPases Activate ROCKsR-HSA-166208:mTORC1-mediated signallingR-HSA-111447:Activation of BAD and translocation to mitochondria
|
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Translocation of GLUT4 to the plasma membrane
|
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
|
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eNOS activation
|
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Integrin alphaIIb beta3 signaling
|
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Deactivation of the beta-catenin transactivating complex
|
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KSRP (KHSRP) binds and destabilizes mRNA
|
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Constitutive Signaling by AKT1 E17K in Cancer
|
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WikiPathways
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Toll-like receptor signaling pathway
|
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DNA Damage Response (only ATM dependent)
|
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ErbB Signaling Pathway
|
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Nanoparticle-mediated activation of receptor signaling
|
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Signal Transduction of S1P Receptor
|
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Signaling Pathways in Glioblastoma
|
|
Integrin-mediated Cell Adhesion
|
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Regulation of toll-like receptor signaling pathwayWP524:G13 Signaling Pathway
|
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Regulation of Actin Cytoskeleton
|
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EGF/EGFR Signaling Pathway
|
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TGF beta Signaling Pathway
|
|
Focal Adhesion
|
|
JAK/STAT
|
|
AGE/RAGE pathway
|
|
Pathogenic Escherichia coli infection
|
|
Regulation of Microtubule Cytoskeleton
|
|
Leptin signaling pathway
|
|
Semaphorin interactions
|
|
GPCR downstream signaling
|
|
Apoptotic execution phase
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Androgen receptor signaling pathwayWP673:ErbB Signaling Pathway
|
|
Interferon type I signaling pathways
|
|
G13 Signaling Pathway
|
|
IL-2 Signaling Pathway
|
|
Insulin Signaling
|
|
Cytoplasmic Ribosomal Proteins
|
|
IL-4 Signaling Pathway
|
|
IL-6 signaling pathway
|
|
Kit receptor signaling pathway
|
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
|
BDNF signaling pathway
|
|
Interleukin-11 Signaling Pathway
|
|
FSH signaling pathway
|
|
TSH signaling pathway
|
|
Signaling by Insulin receptor
|
|
TOR Signaling
|
|
AMPK Signaling
|
|
IL-5 Signaling PathwayWP75:Toll-like receptor signaling pathway
|
|
TCR Signaling Pathway
|
|
Notch Signaling Pathway
|
|
EPO Receptor Signaling
|
|
Endochondral Ossification
|
|
Wnt Signaling Pathway Netpath
|
|
Copper homeostasis
|
|
Extracellular vesicle-mediated signaling in recipient cells
|
|
IL-3 Signaling Pathway
|
|
Cardiac Hypertrophic Response
|
|
Translocation of GLUT4 to the Plasma Membrane
|
|
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
|
PIP3 activates AKT signaling
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Primary Focal Segmental Glomerulosclerosis FSGS
|
|
Apoptosis
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
Corticotropin-releasing hormone
|
|
TNF alpha Signaling Pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Prostate Cancer
|
|
TSLP Signaling Pathway
|
|
IL17 signaling pathway
|
|
IL-7 Signaling Pathway
|
|
TWEAK Signaling Pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Integrated Breast Cancer Pathway
|
|
SREBP signalling
|
|
Integrated Cancer pathway
|
|
IL-1 signaling pathway
|
|
Metabolism of nitric oxide
|
|
TFs Regulate miRNAs related to cardiac hypertrophy
|
|
Angiogenesis
|
|
Regulation of toll-like receptor signaling pathway
|
|
Androgen receptor signaling pathway
|
|
IL-5 Signaling Pathway
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8130). |
|---|
| REF 2 | J Med Chem. 2008 Sep 25;51(18):5663-79.Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. |
|---|
| REF 3 | Bioorg Med Chem Lett. 2005 Jul 15;15(14):3407-11.(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors. |
|---|
