| Drug General Information |
| Drug ID |
D0HP1O
|
| Drug Name |
AF-DX-384
|
| Synonyms |
AF-DX-384; 118290-27-0; AF-DX-384
|
| Drug Type |
Small molecular drug
|
| Indication |
Unspecified
|
Investigative |
[1],
[2]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C27H38N6O2
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M4 |
Target Info |
Modulator |
|
|---|
| Muscarinic acetylcholine receptor M2 |
Target Info |
Modulator |
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
Regulation of actin cytoskeleton
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
|
|
PathWhiz Pathway
|
Muscle/Heart Contraction
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
|
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
Regulation of Actin Cytoskeleton
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
|
|
GPCR downstream signaling
|
|
GPCRs, Other
|
| References |
| REF 1 | M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site. |
|---|
| REF 2 | M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders. |
|---|
