Drug Information

Drug General Information
Drug ID
D0H8QL
Former ID
DAP000722
Drug Name
Mazindol
Synonyms
Diestet; Dimagrir; Magrilon; Mazanor; Mazildene; Mazindole; Mazindolum; Sanjorex; Sanorex; Solucaps; Terenac; Teronac; Teronak; Mazindol Medix Brand; Mazindol Novartis Brand; Mazindol Searle Brand; Mazindol Wyeth Brand; Medix Brand of Mazindol; Novartis Brand of Mazindol; Searle Brand of Mazindol; Wyeth Brand of Mazindol; AN 448;AN448; S 42548; SAH 42548; AN-448; Mazanor (TN); Mazindolum [INN-Latin]; SA 42-548; SANOREX (TN); Sanorex (TN); Mazindol [USAN:BAN:INN]; Mazindol (JAN/USP/INN); (+-)-5-(p-Chlorophenyl)-2,5-dihydro-3H-imidazo(2,1-a)isoindol-5-ol; 5-(4-Chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo(2,1-a)isoindole; 5-(4-Chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol; 5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol; 5-(p-Chlorophenyl)-2,5-dihydro-3H-imidazo(2,1-a)isoindol-5-ol; 5-p-Chlorophenyl-2,3-dihydro-5H-imidazo(2,1-a)isoindol-5-ol; 5H-Imidazo(2,1-a)isoindol-5-ol, 5-(4-chlorophenyl)-2,3-dihydro
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Approved [468026], [535114]
Therapeutic Class
Central Nervous System Stimulants
Structure
Download
2D MOL

3D MOL
Formula
C16H13ClN2O
InChI
InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
InChIKey
ZPXSCAKFGYXMGA-UHFFFAOYSA-N
CAS Number
CAS 22232-71-9
PubChem Compound ID
4020
PubChem Substance ID
5663207, 7847433, 7979864, 8152518, 10514045, 14897762, 24896596, 29223131, 46509094, 48416196, 49978900, 51064091, 53789697, 57322096, 85174591, 92711740, 99431540, 103206445, 103856500, 103919017, 104305195, 125345244, 126630564, 126665962, 129938107, 131305866, 134338010, 134993905, 136949640, 137154621, 143038295, 152034992, 152258665, 160647502, 160830559, 160963924, 163094692, 163393871, 164228469, 164814279, 178101312, 178101499, 179116764, 186022457, 198993257, 204388874, 223664711, 224771980, 226415324, 241041015
SuperDrug ATC ID
A08AA05
SuperDrug CAS ID
cas=022232719
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Modulator [556264]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 468026(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4797).
Ref 535114Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity. Endocrine. 2000 Oct;13(2):193-9.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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