Drug Information

Drug General Information
Drug ID
D0H7KF
Former ID
DAP000001
Drug Name
Quetiapine
Synonyms
Norsic; Quetiapina; Quetiapinum; Seroquel; Quetiapine fumarate; Quetiapine hemifumarate; ZD5077; Co-Quetiapine; Ketipinor (TN); Norsic (TN); Quetiapine (INN); Quetiapine [INN:BAN]; Seroquel (Fumarate); Seroquel (TN); ZM 204,636; 2-(2-(4-Dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)ethanol; 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol; 2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol; 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol; 2-{[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethyl]oxy}ethanol
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Approved [468121], [536773]
Therapeutic Class
Antipsychotic Agents
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C21H25N3O2S
InChI
InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2
InChIKey
URKOMYMAXPYINW-UHFFFAOYSA-N
CAS Number
CAS 111974-69-7
PubChem Compound ID
5002
PubChem Substance ID
9601, 631813, 5198881, 7980444, 8153080, 14756073, 26612817, 26749928, 29215183, 29215184, 29224074, 46504800, 48416505, 49666155, 49666758, 50064167, 50606342, 56312011, 56312821, 56394834, 57288825, 61127934, 85209878, 92308036, 93166437, 93619787, 96025142, 103195252, 103993497, 104307995, 108136177, 114919760, 124799953, 125337908, 126525318, 126653074, 126671681, 127275837, 127275838, 127275839, 127275840, 127275841, 127275842, 127275843, 129409886, 134337331, 134338691, 134339382, 134358152, 135017541
ChEBI ID
ChEBI:8707
SuperDrug ATC ID
N05AH04
SuperDrug CAS ID
cas=111974697
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [535384], [537077]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 468121(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 50).
Ref 536773How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30.
Ref 535384Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38.
Ref 537077Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors. Eur J Pharmacol. 2009 Apr 1;607(1-3):35-40. Epub 2009 Feb 13.

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