Drug Information
Drug General Information | |||||
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Drug ID |
D0H6BG
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Former ID |
DIB020704
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Drug Name |
PHCCC
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Synonyms |
(-) PHCCC
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [538893] | ||
Structure |
Download2D MOL |
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Formula |
C17H14N2O3
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InChI |
InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20)/b19-15-
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InChIKey |
FPXPIEZPAXSELW-CYVLTUHYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Metabotropicglutamate receptor 1 | Target Info | Modulator (allosteric modulator) | [543745] | |
Metabotropic glutamate receptor 4 | Target Info | Modulator (allosteric modulator) | [526858] | ||
mGlu6 receptor | Target Info | Modulator (allosteric modulator) | [529571] | ||
KEGG Pathway | Calcium signaling pathway | ||||
FoxO signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Long-term potentiation | |||||
Retrograde endocannabinoid signaling | |||||
Glutamatergic synapse | |||||
Long-term depression | |||||
Estrogen signaling pathwayhsa04080:Neuroactive ligand-receptor interaction | |||||
Taste transduction | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Metabotropic glutamate receptor group III pathway | |||||
Metabotropic glutamate receptor group I pathway | |||||
Endogenous cannabinoid signalingP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
References | |||||
Ref 526858 | (-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection. Neuropharmacology. 2003 Dec;45(7):895-906. | ||||
Ref 529571 | The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors. Eur J Pharmacol. 2008 Jul 28;589(1-3):49-52. | ||||
Ref 543745 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 289). |
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