| Drug General Information |
| Drug ID |
D0H3NA
|
| Former ID |
DNC003682
|
| Drug Name |
4-Benzo[b]thiophen-4-yl-1H-imidazole
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H8N2S
|
| Canonical SMILES |
C1=CC(=C2C=CSC2=C1)C3=CN=CN3
|
| InChI |
1S/C11H8N2S/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1/h1-7H,(H,12,13)
|
| InChIKey |
QRRRICPYXPJYEH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Alpha-2B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Alpha-1A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-1D adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-1B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-2A adrenergic receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
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AMPK signaling pathway
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Adrenergic signaling in cardiomyocytes
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Vascular smooth muscle contraction
|
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Salivary secretionhsa04020:Calcium signaling pathway
|
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Salivary secretionhsa04022:cGMP-PKG signaling pathway
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NetPath Pathway
|
IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
|
|
Pathway Interaction Database
|
LPA receptor mediated events
|
|
Reactome
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Adrenoceptors
|
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Adrenaline signalling through Alpha-2 adrenergic receptor
|
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G alpha (i) signalling events
|
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G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
|
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G alpha (q) signalling events
|
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G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
|
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Adrenaline,noradrenaline inhibits insulin secretion
|
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G alpha (z) signalling events
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Surfactant metabolism
|
|
WikiPathways
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
|
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Calcium Regulation in the Cardiac Cell
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Gastrin-CREB signalling pathway via PKC and MAPK
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Endothelin Pathways
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GPCR downstream signaling
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AMPK SignalingWP58:Monoamine GPCRs
|
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GPCRs, OtherWP58:Monoamine GPCRs
|
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Vitamin D Receptor Pathway
|
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Integration of energy metabolism
|
| References |
| REF 1 | J Med Chem. 2000 Mar 9;43(5):765-8.alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor. |
|---|
| REF 2 | J Med Chem. 2000 Apr 6;43(7):1423-6.Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the alpha(2D) adrenergic receptor. |
|---|
