Drug General Information
Drug ID
D0H2YM
Former ID
DIB018537
Drug Name
27-hydroxycholesterol
Synonyms
27-OHC; 26-hydroxycholesterol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539797]
Structure
Download
2D MOL
Formula
C27H46O2
InChI
InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKey
FYHRJWMENCALJY-YSQMORBQSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) GPR183 Target Info Agonist [531581]
Oxysterols receptor LXR-alpha Target Info Agonist [526122]
Oxysterols receptor LXR-beta Target Info Agonist [526122]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear ReceptorsWP1982:SREBP signalling
Nuclear Receptors
References
Ref 539797(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2752).
Ref 52612227-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem. 2001 Oct 19;276(42):38378-87. Epub 2001 Aug 14.
Ref 531581Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.