| Drug General Information |
| Drug ID |
D0H2UT
|
| Former ID |
DIB019029
|
| Drug Name |
brucine
|
| Synonyms |
10,11-dimethoxy strychnine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C23H26N2O4
|
| InChI |
InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+/m0/s1
|
| InChIKey |
RRKTZKIUPZVBMF-IBTVXLQLSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
11276, 598388, 840738, 10298947, 14719301, 14903268, 24864782, 26746579, 36885681, 46386939, 47657001, 47880005, 49681539, 57403888, 76762786, 85842983, 87563676, 87563907, 92308664, 93622920, 103654800, 104626693, 118964464, 119501368, 124659063, 124812305, 126609088, 129171059, 134973275, 135652672, 136368363, 136904068, 137171662, 144101886, 144204902, 144212491, 152095097, 152164256, 152248216, 162091246, 162180531, 163123724, 163350061, 163614688, 172080451, 179230492, 198939562, 204378260, 223439149, 223534016
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M3 |
Target Info |
Modulator (allosteric modulator) |
[2]
|
|---|
| Muscarinic receptor |
Target Info |
Modulator (allosteric modulator) |
[2]
|
|
KEGG Pathway
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Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
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Cholinergic synapse
|
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Regulation of actin cytoskeleton
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Insulin secretion
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Salivary secretion
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Gastric acid secretion
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Pancreatic secretionhsa04020:Calcium signaling pathway
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cAMP signaling pathway
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PI3K-Akt signaling pathway
|
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PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
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PathWhiz Pathway
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Gastric Acid ProductionPW000564:Muscle/Heart Contraction
|
|
Reactome
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Muscarinic acetylcholine receptors
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Acetylcholine regulates insulin secretion
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G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
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G alpha (q) signalling events
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WikiPathways
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Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
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Regulation of Actin Cytoskeleton
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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Integration of energy metabolism
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP58:Monoamine GPCRs
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Secretion of Hydrochloric Acid in Parietal Cells
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 342). |
|---|
| REF 2 | Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. Mol Pharmacol. 1998 Mar;53(3):573-89. |
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