Drug Information

Drug General Information
Drug ID
D0H2OA
Former ID
DNC000186
Drug Name
Alpha-monofluoromethyl-3,4-dehydroornithine ethyl ester
Drug Type
Small molecular drug
Indication Discovery agent Investigative [537732]
Structure
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2D MOL

3D MOL
Formula
C8H15FN2O2
Canonical SMILES
CCOC(=O)C(CF)(C=CCN)N
InChI
1S/C8H15FN2O2/c1-2-13-7(12)8(11,6-9)4-3-5-10/h3-4H,2,5-6,10-11H2,1H3/b4-3+
InChIKey
RQVGWIPBGFYUQU-ONEGZZNKSA-N
PubChem Compound ID
6438751
PubChem Substance ID
15265848, 43031723, 74527624, 114556867, 134339690, 135083879, 236214287
Target and Pathway
Target(s) Ornithine decarboxylase Target Info Inhibitor [537732]
BioCyc Pathway Putrescine biosynthesis I
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Ornithine degradation
CCKR signaling map ST
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
PathWhiz Pathway Spermidine and Spermine Biosynthesis
References
Ref 537732Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.
Ref 537732Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.

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