Drug General Information
Drug ID	D0H2NI
Former ID	DIB013658
Drug Name	YM-543
Synonyms	ASP-543; SGLT-2 inhibitor (oral, diabetes), Astellas/Kotobuki
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Phase 2	[521996]
Company	Kotobuki Pharmaceutical Co Ltd
Structure		Download 2D MOL
Target and Pathway
Target(s)	SLGT2	Target Info	Modulator
Reactome	Hexose transport
	Na+-dependent glucose transporters
	Inositol transporters
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 521996	ClinicalTrials.gov (NCT00454233) A Safety and Efficacy Study With YM543 in Type 2 Diabetes Mellitus Subjects. U.S. National Institutes of Health.

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