Drug General Information
Drug ID	D0GS2W
Former ID	DIB011927
Drug Name	W-198
Drug Type	Small molecular drug
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Phase 1	[550040]
Company	Chengdu Kanghong Pharmaceutical Group Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C38H41BrN2O6
PubChem Compound ID	9831563
Target and Pathway
Target(s)	Multidrug resistance protein 1	Target Info	Modulator	[531954]
KEGG Pathway	ABC transporters
	Bile secretion
	MicroRNAs in cancer
NetPath Pathway	IL2 Signaling Pathway
	TCR Signaling Pathway
Pathway Interaction Database	HIF-1-alpha transcription factor network
Reactome	ABC-family proteins mediated transport
WikiPathways	Nuclear Receptors in Lipid Metabolism and Toxicity
	Abacavir transport and metabolism
	Multi Drug Resistance Protein 1 (Glycoprotein 1) Regulation
	Integrated Pancreatic Cancer Pathway
	Allograft Rejection
	Drug Induction of Bile Acid Pathway
	Codeine and Morphine Metabolism
References
Ref 550040	Pharmacokinetics and safety of bromotetrandrine (BrTet,W198) after single-dose intravenous administration in healthy Chinese volunteers. Journal of Clinical Pharmacy and Therapeutics (2010) 35, 113-119.
Ref 531954	Mechanisms of tetrandrine and 5-bromotetrandrine in reversing multidrug resistance may relate to down-regulation of multidrug resistance associated protein 7 expression. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jun;20(3):558-63.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.