Drug Information
Drug General Information | |||||
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Drug ID |
D0GR5L
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Former ID |
DNC003681
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Drug Name |
AL-43
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [526567] | ||
Structure |
Download2D MOL |
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Formula |
C23H25NO2
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Canonical SMILES |
CC1=CC(NC2=C1C3=C(C=C2)C4=C(C=CC=C4OC)OC3CC=C)(C)C
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InChI |
1S/C23H25NO2/c1-6-8-18-22-15(21-17(25-5)9-7-10-19(21)26-18)11-12-16-20(22)14(2)13-23(3,4)24-16/h6-7,9-13,18,24H,1,8H2,2-5H3
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InChIKey |
CZSDJYXNNJQXBB-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | mRNA of glucocorticoid receptor | Target Info | Inhibitor | [527002] | |
mRNA of androgen receptor | Target Info | Inhibitor | [526567] | ||
Progesterone receptor | Target Info | Inhibitor | [526567] | ||
Mineralocorticoid receptor | Target Info | Inhibitor | [526567] | ||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
Signaling events mediated by HDAC Class II | |||||
FOXA2 and FOXA3 transcription factor networks | |||||
Glucocorticoid receptor regulatory network | |||||
Regulation of Androgen receptor activity | |||||
AP-1 transcription factor networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling | |||||
Coregulation of Androgen receptor activity | |||||
Nongenotropic Androgen signaling | |||||
Regulation of nuclear beta catenin signaling and target gene transcription | |||||
FOXA1 transcription factor network | |||||
Notch-mediated HES/HEY networkanthraxpathway:Cellular roles of Anthrax toxin | |||||
PathWhiz Pathway | Kidney Function | ||||
WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
SIDS Susceptibility Pathways | |||||
Endoderm Differentiation | |||||
Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||||
Adipogenesis | |||||
Circadian Clock | |||||
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways | |||||
Integrated Pancreatic Cancer Pathway | |||||
Prostate Cancer | |||||
Integrated Breast Cancer Pathway | |||||
Nuclear Receptors | |||||
Androgen receptor signaling pathwayWP34:Ovarian Infertility Genes | |||||
Signaling by ERBB4 | |||||
Nuclear ReceptorsWP554:ACE Inhibitor Pathway | |||||
References | |||||
Ref 526567 | J Med Chem. 2003 Mar 13;46(6):1016-30.Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines. | ||||
Ref 527002 | Bioorg Med Chem Lett. 2004 Apr 5;14(7):1721-7.Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators. |
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