Drug Information

Drug General Information
Drug ID
D0G5CF
Former ID
DCL000782
Drug Name
Doxercalciferol
Synonyms
Doxcercalciferol; Hectorol; Doxercalciferol [INN]; TSA 840; BCI-101; Doxercalciferol (INN); Hectorol (TN); (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1alpha,3beta-diol; 1-Hydroxyergocalciferol; 1-alpha-Hydroxyvitamin D2; 1alpha-Hydroxyergocalciferol; 1alpha-OH-D2; 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol,(1-alpha,3-beta,5Z,7E,22E)
Drug Type
Small molecular drug
Indication Chronic kidney disease; Kidney transplantation [ICD9: 403, 580-589, 585.1-585.5, 585.9, 996; ICD10:N00-N29, N18, T86] Approved [537117], [539836]
Company
Genzyme
Structure
Download
2D MOL

3D MOL
Formula
C28H44O2
InChI
InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
InChIKey
HKXBNHCUPKIYDM-CGMHZMFXSA-N
CAS Number
CAS 54573-75-0
PubChem Compound ID
5281107
PubChem Substance ID
10410, 7848072, 8616516, 11528742, 14714977, 14757783, 14831187, 26759741, 39290018, 47721666, 50096685, 50140476, 53790000, 57358018, 71855033, 103770793, 109693717, 113854564, 126670553, 127324039, 127324040, 127324041, 134957119, 135079074, 135651481, 135698305, 137248797, 142560574, 143493351, 144206531, 152164533, 152238015, 152258777, 160647628, 162189015, 163687121, 164227093, 165238070, 175266149, 176264149, 184593516, 184812060, 210277996, 223439572, 223860398, 226660079, 251915651, 251917001, 252157093, 252160414
SuperDrug ATC ID
H05BX03
Target and Pathway
Target(s) Vitamin D receptor Target Info Antagonist [537117]
KEGG Pathway Endocrine and other factor-regulated calcium reabsorption
Mineral absorption
Tuberculosis
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Vitamin D metabolism and pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Direct p53 effectors
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
Reactome Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
Vitamin D Metabolism
References
Ref 537117Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63.
Ref 539836(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2790).
Ref 537117Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.