Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0G3YC
|
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| Former ID |
DIB002605
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| Drug Name |
Netupitant
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| Synonyms |
R-1124; NK1 antagonist (emesis), Roche; Ro-67-3189
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| Drug Type |
Small molecular drug
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| Company |
Helsinn Therapeutics
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| Structure |
|
Download2D MOL |
|||
| Formula |
C30H32F6N4O
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| InChI |
InChI=1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3
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| InChIKey |
WAXQNWCZJDTGBU-UHFFFAOYSA-N
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| CAS Number |
CAS 290297-26-6
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
11972336, 15109574, 43042117, 47206876, 50788120, 57370279, 103482309, 104063884, 114526492, 125683129, 126671554, 135246549, 137248756, 142494945, 162830915, 178102368, 179323031, 198988386, 210275497, 210281145, 223666980, 223771059, 226767714, 246332907, 249807117, 250163183, 251971119, 252215904, 252480189
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| Target and Pathway | |||||
| Target(s) | Substance-P receptor | Target Info | Antagonist | [532860] | |
| PANTHER Pathway | CCKR signaling map ST | ||||
| Reactome | G alpha (q) signalling events | ||||
| References | |||||
| Ref 523441 | ClinicalTrials.gov (NCT01339260) An Efficacy and Safety Study of Oral Netupitant and Palonosetron for the Prevention of Nausea and Vomiting. U.S. National Institutes of Health. | ||||
| Ref 541077 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5742). | ||||
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