Drug Information
Drug General Information | |||||
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Drug ID |
D0G2QH
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Former ID |
DCL000361
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Drug Name |
AEE-788
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Synonyms |
AEE; AEE 788; AEE788; GNF-Pf-5343; AEE-788, NVP-AEE 788, AEE788
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Drug Type |
Small molecular drug
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Therapeutic Class |
Anticancer Agents
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Company |
Novartis AG
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Structure |
Download2D MOL |
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Formula |
C27H32N6
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InChI |
InChI=1S/C27H32N6/c1-3-32-13-15-33(16-14-32)18-21-9-11-23(12-10-21)25-17-24-26(28-19-29-27(24)31-25)30-20(2)22-7-5-4-6-8-22/h4-12,17,19-20H,3,13-16,18H2,1-2H3,(H2,28,29,30,31)/t20-/m1/s1
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InChIKey |
OONFNUWBHFSNBT-HXUWFJFHSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Fibroblast growth factor receptor 2 | Target Info | Inhibitor | [536474] | |
FGF-3 receptor | Target Info | Inhibitor | [536474] | ||
KEGG Pathway | MAPK signaling pathway | ||||
Ras signaling pathway | |||||
Rap1 signaling pathway | |||||
Endocytosis | |||||
PI3K-Akt signaling pathway | |||||
Signaling pathways regulating pluripotency of stem cells | |||||
Regulation of actin cytoskeleton | |||||
Pathways in cancer | |||||
Prostate cancer | |||||
Central carbon metabolism in cancerhsa04010:MAPK signaling pathway | |||||
MicroRNAs in cancer | |||||
Bladder cancer | |||||
Central carbon metabolism in cancer | |||||
NetPath Pathway | IL1 Signaling Pathway | ||||
PANTHER Pathway | FGF signaling pathwayP00021:FGF signaling pathway | ||||
Pathway Interaction Database | FGF signaling pathway | ||||
WikiPathways | Regulation of Actin Cytoskeleton | ||||
Ectoderm Differentiation | |||||
Hair Follicle Development: Organogenesis (Part 2 of 3) | |||||
Hair Follicle Development: Induction (Part 1 of 3) | |||||
Cardiac Hypertrophic Response | |||||
Signaling Pathways in Glioblastoma | |||||
Neural Crest Differentiation | |||||
Signaling by FGFR | |||||
MicroRNAs in cardiomyocyte hypertrophy | |||||
AngiogenesisWP51:Regulation of Actin Cytoskeleton | |||||
Endochondral Ossification | |||||
Bladder Cancer | |||||
References | |||||
Ref 521635 | ClinicalTrials.gov (NCT00107237) AEE788 and Everolimus in Treating Patients With Recurrent or Relapsed Glioblastoma Multiforme. U.S. National Institutes of Health. | ||||
Ref 542626 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7643). |
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