Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0G0UZ
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| Former ID |
DIB001587
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| Drug Name |
SBP-002
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| Synonyms |
Coramsine; Solasonine + solamargine; Solasodine glycosides (cancer, injectable formulation), Solbec; Solasodine glycosides (psoriasis, cream formulation), Solbec; Solasonine + solamargine (cancer), Solbec; Solasonine + solamargine (psoriasis), Solbec; SBP-002 (intravenous, cancer), Solbec; SBP-002 (psoriasis, cream formulation), Solbec
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| Indication | Melanoma [ICD9: 172; ICD10:C43] | Terminated | [1] | ||
| Company |
Curacel International Pty Ltd; Freedom Eye Ltd
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
[C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O[C@H]1[C<br />@@H](O)[C@H](O[C@@H](O[C@H]2CC[C@]3(C(=CC[C@@H]4[C@@H]3<br />CC[C@]3([C@H]4C[C@H]4[C@@H]3[C@@H]([C@@]3(CC[C@H](CN3)C<br />)O4)C)C)C2)C)[C@@H]1O[C@@H]1O[C@H]([C@@H]([C@H]([C@H]1O<br />)O)O)C)CO.[C@@H]1([C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O<br />)O[C@@H]1[C@H](O[C@@H](O[C@H]2CC[C@]3(C(=CC[C@@H]4[C@@H<br />]3CC[C@]3([C@H]4C[C@H]4[C@@H]3[C@@H]([C@@]3(CC[C@H](CN3<br />)C)O4)C)C)C2)C)[C@@H]([C@H]1O)O[C@@H]1O[C@H]([C@@H]([C@<br />H]([C@H]1O)O)O)C)CO
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| Target and Pathway | |||||
| Target(s) | Interleukin-6 receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| HIF-1 signaling pathway | |||||
| PI3K-Akt signaling pathway | |||||
| Jak-STAT signaling pathway | |||||
| Hematopoietic cell lineage | |||||
| Non-alcoholic fatty liver disease (NAFLD) | |||||
| Reactome | MAPK3 (ERK1) activation | ||||
| MAPK1 (ERK2) activation | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Senescence and Autophagy in Cancer | |||||
| IL-6 signaling pathway | |||||
| Differentiation Pathway | |||||
| Interleukin-6 signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022850) | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | ||||
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